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| Pullulan |
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| Add time:[09-05-19 19:03:17] Hits:[] |
Product name: Pullulan
Pullulan is a natural water-soluble polysaccharide, produced from starch by fermentation. Available as a white powder it is odorless, flavorless, and awful stable. Pullulan consists of maltotriose units affiliated through
¦Á 1,6- glucosidic bonds.
Pullulan has many proven uses in the pharmaceutical industry:
Non-animal capsules
Tabletting Excipient
Tablet coating
Powder agglomeration
Pullulan is used by Capsugel to manufacture NPcaps™ an all-natural, two-piece non-animal capsule suitable for addressing a variety of cultural and dietary requirements, including those of vegetarians, diabetics and patients with restricted diets.
Pullulan is very stable and well-characterized, and has achieved wide regulatory acceptance with its proven safety record. It has been in commercial production for more than 25 years, having numerous uses in the food and pharmaceutical industries.
Capsugel offers its high-performing NPcaps capsules when a non-animal, all natural capsule is preferred.
Perfectly Suited for Pharmaceutical Applications
NPcaps are designed to support non-animal formulation initiatives, as well as address patients¡¯ dietary and cultural requirements. Made from all natural pullulan, NPcaps offer similar stability, dissolution and disintegration, machinability, appearance and manufacturing dimensions as Capsugel¡¯s popular Coni-Snap® gelatin capsules.
Chemical Stability
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Non-cross-linking |
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Compatible with all major excipients, including: lactose, maize starch, sorbitol, magnesium stearate, pre-gelatinized starch, microcrystalline cellulose and carboxymethylcellulose |
Mechanical Stability
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Similar to gelatin, moisture control assures flexibility of the capsule shell
- Studies show 0% broken capsules at standard manufacturing conditions (50% RH) |
Dissolution
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In vivo studies confirm that disintegration occurs quickly in the stomach, similar to gelatin |
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In vitro studies with acetaminophen closely match the dissolution profile of gelatin across the entire pH range |
Machinability
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NPcaps capsule dimensions are identical to gelatin |
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Machinability tests have been successfully conducted with major CFM manufacturers |
Appearance
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Side by side, gelatin and NPcaps are virtually identical and utilize similar colorants |
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To assure patient compliance, NPcaps capsules match the look and feel of gelatin, with the same lusterous sheen and smooth capsule surface |
The Natural Balance Between Health and Technology
With the trend moving towards healthier lifestyles, consumers are becoming more and more selective. That¡¯s why Capsugel is one step ahead of the development curve with NPcaps ¨C a highly effective encapsulation option for dietary supplement products.
NPcaps are odorless, tasteless, and completely biodegradable two-piece capsules made from the completely natural, vegetable-derived polysaccharide, pullulan. Because pullulan is the capsule material most impermeable to oxygen transmission, NPcaps are highly recommended for encapsulating oxidation-sensitive ingredients to provide enhanced protection.
For more information on NPcaps, visit Capsugel¡¯s web site at www.capsugel.com
Tabletting Excipient
Granular pullulan can be used as a tabletting excipient to improve the tabletting performance of excipients and actives.
Tablet Coating
Pan coating performance can be improved by using ingredients that improve adhesion and shine without increasing the viscosity of the coating syrup. In these respects Pullulan with its excellent adhesive properties and extremely low viscosity is ideally suited for tablet coating. When used in a base coat Pullulan provides improved coating adhesion compared to gum arabic.
When used in a top coat, Pullulan¡¯s adhesive properties significantly increases the strength and resilience of the coating reducing damage during transport and distribution.
Powder Agglomeration
Pullulan has approximately double the adhesive strength of food starch. This property combined with its lack of flavor enables it to be used effectively in typical agglomeration processes.
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